1 keywords

CATH Domain 3n7oA01

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.40 Beta Barrel
Topology 2.40.10 Thrombin, subunit H
Homologous Superfamily 2.40.10.10 Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Complement factor D

Enzyme Information

3.4.21.39
Chymase.
based on mapping to UniProt P23946
Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.
-!- In mast cell granules. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P23946
CMA1_HUMAN
Homo sapiens
Chymase

PDB Structure

PDB 3N7O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Potency variation of small-molecule chymase inhibitors across species.
Kervinen, J., Crysler, C., Bayoumy, S., Abad, M.C., Spurlino, J., Deckman, I., Greco, M.N., Maryanoff, B.E., de Garavilla, L.
Biochem. Pharmacol.