1 keywords

CATH Domain 3n3zA00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1300 Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
Homologous Superfamily 1.10.1300.10 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase 9A

Enzyme Information

3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt O76083
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

O76083
PDE9A_HUMAN
Homo sapiens
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

PDB Structure

PDB 3N3Z
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of PDE9A (E406A) mutation in complex with IBMX
Hou, J., Luo, H.-B., Chen, Y., Xu, J., Zhao, R., Zou, L.
To be Published