CATH Classification

Domain Context

CATH Clusters

Superfamily Lyase, Ornithine Decarboxylase; Chain A, domain 1
Functional Family

Enzyme Information

4.1.1.96
Carboxynorspermidine decarboxylase.
based on mapping to UniProt A8FNH9
(1) Carboxynorspermidine = bis(3-aminopropyl)amine + CO(2). (2) Carboxyspermidine = spermidine + CO(2).
-!- Part of a bacterial polyamine biosynthesis pathway. -!- The enzyme is essential for biofilm formation in the bacterium Vibrio cholerae. -!- The enzyme from Campylobacter jejuni only produces spermidine in vivo even though it shows activity with carboxynorspermidine in vitro.

UniProtKB Entries (1)

A8FNH9
NSPC_CAMJ8
Campylobacter jejuni subsp. jejuni 81116
Carboxynorspermidine/carboxyspermidine decarboxylase

PDB Structure

PDB 3N29
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.
Deng, X., Lee, J., Michael, A.J., Tomchick, D.R., Goldsmith, E.J., Phillips, M.A.
J.Biol.Chem.