CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family Three prime repair exonuclease 1

Enzyme Information

3.1.11.2
Exodeoxyribonuclease III.
based on mapping to UniProt Q91XB0
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
-!- Preference for double-stranded DNA. -!- Has endonucleolytic activity near apurinic sites on DNA. -!- Similar enzyme: Haemophilus influenzae exonuclease. -!- Formerly EC 3.1.4.27.

UniProtKB Entries (1)

Q91XB0
TREX1_MOUSE
Mus musculus
Three-prime repair exonuclease 1

PDB Structure

PDB 3MXI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray Crystal Structures of TREX1 3' Exonuclease Autoimmune Disease Mutants
Bailey, S.L., Harvey, S., Perrino, F.W., Hollis, T.
To be Published