CATH Classification

Domain Context

CATH Clusters

Superfamily Butyryl-CoA Dehydrogenase, subunit A, domain 3
Functional Family Acyl-CoA dehydrogenase

Enzyme Information

1.3.99.32
Glutaryl-CoA dehydrogenase (acceptor).
based on mapping to UniProt C3UVB0
Glutaryl-CoA + acceptor = (E)-glutaconyl-CoA + reduced acceptor.
-!- The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (EC 1.3.8.6), and a nondecarboxylating enzyme (this entry). -!- The two enzymes cause different structural changes around the glutaconyl carboxylate group, primarily due to the presence of either a tyrosine or a valine residue, respectively, at the active site.

UniProtKB Entries (1)

C3UVB0
ACD_DESML
Desulfococcus multivorans
Glutaryl-CoA dehydrogenase

PDB Structure

PDB 3MPJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases.
Wischgoll, S., Demmer, U., Warkentin, E., Gunther, R., Boll, M., Ermler, U.
Biochemistry