CATH Classification

Domain Context

CATH Clusters

Superfamily Butyryl-CoA Dehydrogenase, subunit A, domain 3
Functional Family Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Enzyme Information

1.3.8.7
Medium-chain acyl-CoA dehydrogenase.
based on mapping to UniProt P41367
A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
-!- One of several enzymes that catalyze the first step in fatty acids beta-oxidation. -!- The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C(8) to C(12) compounds. -!- The enzyme from rat does not accept C(16) at all and is most active with C(6)-C(8) compounds. -!- cf. EC 1.3.8.1, EC 1.3.8.8 and EC 1.3.8.9. -!- Formerly EC 1.3.2.2 and EC 1.3.99.3.

UniProtKB Entries (1)

P41367
ACADM_PIG
Sus scrofa
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

PDB Structure

PDB 3MDD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate.
Kim, J.J., Wang, M., Paschke, R.
Proc.Natl.Acad.Sci.USA