CATH Classification

Domain Context

CATH Clusters

Superfamily Zinc/RING finger domain, C3HC4 (zinc finger)
Functional Family Ubiquitin carboxyl-terminal hydrolase 8

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt P50102
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

P53165
SGF73_YEAST
Saccharomyces cerevisiae S288C
SAGA-associated factor 73

PDB Structure

PDB 3M99
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module.
Kohler, A., Zimmerman, E., Schneider, M., Hurt, E., Zheng, N.
Cell(Cambridge,Mass.)