CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P49137
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P49137
MAPK2_HUMAN
Homo sapiens
MAP kinase-activated protein kinase 2

PDB Structure

PDB 3M42
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel pyrrolo[2,3-f]isoquinoline based MAPKAP-K2 (MK2) inhibitors with potent in vitro and in vivo activity
Revesz, L., Schlapbach, A., Aichholz, R., Feifel, R., Hawtin, S., Heng, R., Hiestand, P., Jahnke, W., Koch, G., Moebitz, H., Scheufler, C., Velcicky, J., Huppertz, C.
To be Published