CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Glycogen synthase kinase-3 beta

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P49841
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.11.26
[Tau protein] kinase.
based on mapping to UniProt P49841
ATP + [tau protein] = ADP + [tau protein] phosphate.
-!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.

UniProtKB Entries (1)

P49841
GSK3B_HUMAN
Homo sapiens
Glycogen synthase kinase-3 beta

PDB Structure

PDB 3M1S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3beta
Atilla-Gokcumen, G.E., Di Costanzo, L., Meggers, E.
J.Biol.Inorg.Chem.