CATH Classification

Domain Context

CATH Clusters

Superfamily Diphthamide synthesis DPH1/DPH2 domain 2
Functional Family 2-(3-amino-3-carboxypropyl)histidine synthase

Enzyme Information

2.5.1.108
2-(3-amino-3-carboxypropyl)histidine synthase.
based on mapping to UniProt O58832
L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine.
-!- Modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical. -!- The enzyme is present in archae and eukaryotes but not in eubacteria. -!- Part of diphthamide biosynthesis. -!- Formerly EC 2.5.1.n7.

UniProtKB Entries (1)

O58832
DPH2_PYRHO
Pyrococcus horikoshii OT3
2-(3-amino-3-carboxypropyl)histidine synthase

PDB Structure

PDB 3LZC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme.
Zhang, Y., Zhu, X., Torelli, A.T., Lee, M., Dzikovski, B., Koralewski, R.M., Wang, E., Freed, J., Krebs, C., Ealick, S.E., Lin, H.
Nature