CATH Domain 3lz6A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146

11-beta-hydroxysteroid dehydrogenase.

based on mapping to UniProt Q6QLL4

An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

DHI1_CAVPO

Cavia porcellus

Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB	3LZ6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors. Cheng, H., Hoffman, J., Le, P., Nair, S.K., Cripps, S., Matthews, J., Smith, C., Yang, M., Kupchinsky, S., Dress, K., Edwards, M., Cole, B., Walters, E., Loh, C., Ermolieff, J., Fanjul, A., Bhat, G.B., Herrera, J., Pauly, T., Hosea, N., Paderes, G., Rejto, P. Bioorg.Med.Chem.Lett.