CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P29597
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P29597
TYK2_HUMAN
Homo sapiens
Non-receptor tyrosine-protein kinase TYK2

PDB Structure

PDB 3LXP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
Chrencik, J.E., Patny, A., Leung, I.K., Korniski, B., Emmons, T.L., Hall, T., Weinberg, R.A., Gormley, J.A., Williams, J.M., Day, J.E., Hirsch, J.L., Kiefer, J.R., Leone, J.W., Fischer, H.D., Sommers, C.D., Huang, H.C., Jacobsen, E.J., Tenbrink, R.E., Tomasselli, A.G., Benson, T.E.
J.Mol.Biol.