CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Carbonic anhydrase 2

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt P00915
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00915
CAH1_HUMAN
Homo sapiens
Carbonic anhydrase 1

PDB Structure

PDB 3LXE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: the carbonic anhydrase I-topiramate complex.
Alterio, V., Monti, S.M., Truppo, E., Pedone, C., Supuran, C.T., De Simone, G.
Org.Biomol.Chem.