CATH Classification

Domain Context

CATH Clusters

Superfamily RNA polymerase Rpb2, domain 2
Functional Family DNA-directed RNA polymerase subunit beta

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P0A8V2
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P0A8V2
RPOB_ECOLI
Escherichia coli K-12
DNA-directed RNA polymerase subunit beta

PDB Structure

PDB 3LTI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Complete structural model of Escherichia coli RNA polymerase from a hybrid approach.
Opalka, N., Brown, J., Lane, W.J., Twist, K.A., Landick, R., Asturias, F.J., Darst, S.A.
Plos Biol.