CATH Classification

Domain Context

CATH Clusters

Superfamily Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
Functional Family Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P04412
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q01083
SPITZ_DROME
Drosophila melanogaster
Protein spitz

PDB Structure

PDB 3LTF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for negative cooperativity in growth factor binding to an EGF receptor.
Alvarado, D., Klein, D.E., Lemmon, M.A.
Cell(Cambridge,Mass.)