CATH Classification

Domain Context

CATH Clusters

Superfamily Zinc/RING finger domain, C3HC4 (zinc finger)
Functional Family

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q03164
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q03164
KMT2A_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase 2A

PDB Structure

PDB 3LQH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.
Wang, Z., Song, J., Milne, T.A., Wang, G.G., Li, H., Allis, C.D., Patel, D.J.
Cell(Cambridge,Mass.)