CATH Domain 3loxA02

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Genome polyprotein

Enzyme Information

UniProtKB Entries (1)

Q9ELS8_9HEPC

Hepatitis C virus subtype 1a

Genome polyprotein

PDB Structure

PDB	3LOX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor. Bennett, F., Huang, Y., Hendrata, S., Lovey, R., Bogen, S.L., Pan, W., Guo, Z., Prongay, A., Chen, K.X., Arasappan, A., Venkatraman, S., Velazquez, F., Nair, L., Sannigrahi, M., Tong, X., Pichardo, J., Cheng, K.C., Girijavallabhan, V.M., Saksena, A.K., Njoroge, F.G. Bioorg.Med.Chem.Lett.