CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Serine/threonine-protein kinase/endoribonuclease IRE1

Enzyme Information

3.1.26.-
Endoribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt P32361
2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P32361
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P32361
IRE1_YEAST
Saccharomyces cerevisiae S288C
Serine/threonine-protein kinase/endoribonuclease IRE1

PDB Structure

PDB 3LJ2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.
Wiseman, R.L., Zhang, Y., Lee, K.P., Harding, H.P., Haynes, C.M., Price, J., Sicheri, F., Ron, D.
Mol.Cell