CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.300.30
Functional Family D-alanine--D-alanyl carrier protein ligase

Enzyme Information

6.2.1.54
D-alanine--[D-alanyl-carrier protein] ligase.
based on mapping to UniProt Q99ZA6
ATP + D-alanine + holo-[D-alaninyl-carrier protein] = AMP + diphosphate + D-alanyl-[D-alanyl-carrier protein].
-!- The enzyme is involved in the modification of wall teichoic acids, as well as type I and IV lipoteichoic acids, with D-alanine residues. -!- It activates D-alanine using ATP to form a high-energy (D-alanyl)adenylate intermediate and subsequently transfers the alanyl moiety to the phosphopantheinyl prosthetic group of a D-alanyl-carrier protein (DltC).

UniProtKB Entries (1)

Q99ZA6
DLTA_STRP1
Streptococcus pyogenes serotype M1
D-alanine--D-alanyl carrier protein ligase

PDB Structure

PDB 3LGX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of probable D-alanine-poly(phosphoribitol) ligase subunit-1 from Streptococcus pyogenes with ATP
Ramagopal, U.A., Toro, R., Burley, S.K., Almo, S.C.
To be published