CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.30.30
Functional Family heat shock 70 kDa protein-like

Enzyme Information

3.6.4.10
Non-chaperonin molecular chaperone ATPase.
based on mapping to UniProt P11021
ATP + H(2)O = ADP + phosphate.
-!- This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. -!- They comprise a number of heat-shock-cognate proteins. -!- They are also active in clathrin uncoating and in the oligomerization of actin.

UniProtKB Entries (1)

P11021
BIP_HUMAN
Homo sapiens
Endoplasmic reticulum chaperone BiP

PDB Structure

PDB 3LDN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity.
Macias, A.T., Williamson, D.S., Allen, N., Borgognoni, J., Clay, A., Daniels, Z., Dokurno, P., Drysdale, M.J., Francis, G.L., Graham, C.J., Howes, R., Matassova, N., Murray, J.B., Parsons, R., Shaw, T., Surgenor, A.E., Terry, L., Wang, Y., Wood, M., Massey, A.J.
J.Med.Chem.