1 keywords

CATH Domain 3ldhA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.110 L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
Homologous Superfamily 3.90.110.10 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt P00341
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

P00341
LDHA_SQUAC
Squalus acanthias
L-lactate dehydrogenase A chain

PDB Structure

PDB 3LDH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A comparison of the structures of apo dogfish M4 lactate dehydrogenase and its ternary complexes.
White, J.L., Hackert, M.L., Buehner, M., Adams, M.J., Ford, G.C., Lentz Jr., P.J., Smiley, I.E., Steindel, S.J., Rossmann, M.G.
J.Mol.Biol.