CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P07333
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P07333
CSF1R_HUMAN
Homo sapiens
Macrophage colony-stimulating factor 1 receptor

PDB Structure

PDB 3LCO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.
Meyers, M.J., Pelc, M., Kamtekar, S., Day, J., Poda, G.I., Hall, M.K., Michener, M.L., Reitz, B.A., Mathis, K.J., Pierce, B.S., Parikh, M.D., Mischke, D.A., Long, S.A., Parlow, J.J., Anderson, D.R., Thorarensen, A.
Bioorg.Med.Chem.Lett.