CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Coagulation factor X

Enzyme Information

3.4.21.22
Coagulation factor IXa.
based on mapping to UniProt P00740
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
-!- The proenzyme factor IX is activated by EC 3.4.21.27. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00740
FA9_HUMAN
Homo sapiens
Coagulation factor IX

PDB Structure

PDB 3LC5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure Based Drug Design: Development of Potent and Selective Factor IXa (FIXa) Inhibitors.
Wang, S., Beck, R., Burd, A., Blench, T., Marlin, F., Ayele, T., Buxton, S., Dagostin, C., Malic, M., Joshi, R., Barry, J., Sajad, M., Cheung, C., Shaikh, S., Chahwala, S., Chander, C., Baumgartner, C., Holthoff, H.P., Murray, E., Blackney, M., Giddings, A.
J.Med.Chem.