CATH Classification

Domain Context

CATH Clusters

Superfamily HAD superfamily/HAD-like
Functional Family D,D-heptose 1,7-bisphosphate phosphatase

Enzyme Information

3.1.3.82
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase.
based on mapping to UniProt P63228
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(2)O = D-glycero-beta- D-manno-heptose 1-phosphate + phosphate.
-!- The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno- heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria. -!- In vitro the catalytic efficiency with the beta-anomer is 100-200- fold higher than with the alpha-anomer.

UniProtKB Entries (1)

P63228
GMHBB_ECOLI
Escherichia coli K-12
D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase

PDB Structure

PDB 3L8E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Determinants of Substrate Recognition in the HAD Superfamily Member d-glycero-d-manno-Heptose-1,7-bisphosphate Phosphatase (GmhB) .
Nguyen, H.H., Wang, L., Huang, H., Peisach, E., Dunaway-Mariano, D., Allen, K.N.
Biochemistry