CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.11820
Functional Family

Enzyme Information

2.7.8.12
Teichoic acid poly(glycerol phosphate) polymerase.
based on mapping to UniProt Q5HLM5
n CDP-glycerol + 4-O-((2R)-glycerophospho)-N-acetyl-beta-D-mannosaminyl- (1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis- undecaprenol = n CMP + 4-O-(((2R)-glycerophospho)n-(2R)-glycerophospho)- N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl- diphospho-ditrans,octacis-undecaprenol.
-!- Involved in the biosynthesis of poly glycerol phosphate teichoic acids in bacterial cell walls. -!- This enzyme adds 30-50 glycerol units to the linker molecule, but only after it has been primed with the first glycerol unit by EC 2.7.8.44. -!- Cf. EC 2.7.8.45.

UniProtKB Entries (1)

Q5HLM5
TAGF_STAEQ
Staphylococcus epidermidis RP62A
Teichoic acid poly(glycerol phosphate) polymerase

PDB Structure

PDB 3L7M
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis.
Lovering, A.L., Lin, L.Y., Sewell, E.W., Spreter, T., Brown, E.D., Strynadka, N.C.
Nat.Struct.Mol.Biol.