CATH Classification

Domain Context

CATH Clusters

Superfamily HAD superfamily/HAD-like
Functional Family D,D-heptose 1,7-bisphosphate phosphatase

Enzyme Information

3.1.3.82
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase.
based on mapping to UniProt P63228
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(2)O = D-glycero-beta- D-manno-heptose 1-phosphate + phosphate.
-!- The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno- heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria. -!- In vitro the catalytic efficiency with the beta-anomer is 100-200- fold higher than with the alpha-anomer.

UniProtKB Entries (1)

P63228
GMHBB_ECOLI
Escherichia coli K-12
D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase

PDB Structure

PDB 3L1U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coli.
Taylor, P.L., Sugiman-Marangos, S., Zhang, K., Valvano, M.A., Wright, G.D., Junop, M.S.
Biochemistry