CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.670
Functional Family

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt Q59961
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P72525
PARC_STRPN
Streptococcus pneumoniae TIGR4
DNA topoisomerase 4 subunit A

PDB Structure

PDB 3KSB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases
Laponogov, I., Pan, X.-S., Veselkov, D.A., McAuley, K.E., Fisher, L.M., Sanderson, M.R.
Plos One