CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family G protein-coupled receptor kinase

Enzyme Information

2.7.11.15
[Beta-adrenergic-receptor] kinase.
based on mapping to UniProt P25098
ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.
-!- Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. -!- Does not act on casein or histones. -!- Inhibited by Zn(2+) and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14 and EC 2.7.11.16). -!- Formerly EC 2.7.1.126.

UniProtKB Entries (2)

P63212
GBG2_BOVIN
Bos taurus
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
P25098
ARBK1_HUMAN
Homo sapiens
Beta-adrenergic receptor kinase 1

PDB Structure

PDB 3KRX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
Tesmer, J.J., Tesmer, V.M., Lodowski, D.T., Steinhagen, H., Huber, J.
J.Med.Chem.