CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P04190
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P04190
BLA2_BACCE
Bacillus cereus
Metallo-beta-lactamase type 2

PDB Structure

PDB 3KNS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Metallo-beta-lactamases withstand low Zn(II) conditions by tuning metal-ligand interactions.
Gonzalez, J.M., Meini, M.R., Tomatis, P.E., Medrano Martin, F.J., Cricco, J.A., Vila, A.J.
Nat.Chem.Biol.