CATH Domain 3kfdI00
|Functional Family||Receptor protein serine/threonine kinase|
Receptor protein serine/threonine kinase.
based on mapping to UniProt P36897
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 184.108.40.206.
UniProtKB Entries (1)
Transforming growth factor beta-1 proprotein
Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily.