CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P49137
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P49137
MAPK2_HUMAN
Homo sapiens
MAP kinase-activated protein kinase 2

PDB Structure

PDB 3KC3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode.
Argiriadi, M.A., Ericsson, A.M., Harris, C.M., Banach, D.L., Borhani, D.W., Calderwood, D.J., Demers, M.D., Dimauro, J., Dixon, R.W., Hardman, J., Kwak, S., Li, B., Mankovich, J.A., Marcotte, D., Mullen, K.D., Ni, B., Pietras, M., Sadhukhan, R., Sousa, S., Tomlinson, M.J., Wang, L., Xiang, T., Talanian, R.V.
Bioorg.Med.Chem.Lett.