CATH Classification

Domain Context

CATH Clusters

Superfamily Amidase signature (AS) domain
Functional Family Fatty-acid amide hydrolase 1

Enzyme Information

3.5.1.99
Fatty acid amide hydrolase.
based on mapping to UniProt P97612
(1) Anandamide + H(2)O = arachidonic acid + ethanolamine. (2) Oleamide + H(2)O = oleic acid + NH(3).
-!- Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia. -!- Formerly EC 3.5.1.n2.

UniProtKB Entries (1)

P97612
FAAH1_RAT
Rattus norvegicus
Fatty-acid amide hydrolase 1

PDB Structure

PDB 3K83
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.
Mileni, M., Garfunkle, J., Ezzili, C., Kimball, F.S., Cravatt, B.F., Stevens, R.C., Boger, D.L.
J.Med.Chem.