CATH Classification

Domain Context

CATH Clusters

Superfamily Acetylglutamate kinase-like
Functional Family

Enzyme Information

2.7.4.26
Isopentenyl phosphate kinase.
based on mapping to UniProt Q60352
ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate.
-!- The enzyme is involved in the mevalonate pathway in Archaea. -!- The activity has also been identified in the plant Mentha piperita (peppermint). -!- It is strictly specific for ATP but can use other phosphate acceptors such as dimethylallyl phosphate, geranyl phosphate, or fosfomycin.

UniProtKB Entries (1)

Q60352
IPK_METJA
Methanocaldococcus jannaschii DSM 2661
Isopentenyl phosphate kinase

PDB Structure

PDB 3K4O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mutation of archaeal isopentenyl phosphate kinase highlights mechanism and guides phosphorylation of additional isoprenoid monophosphates.
Dellas, N., Noel, J.P.
Acs Chem.Biol.