CATH Classification

Domain Context

CATH Clusters

Superfamily Aldehyde Dehydrogenase; Chain A, domain 1
Functional Family Succinate-semialdehyde dehydrogenase I

Enzyme Information

1.2.1.-
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt P25526
1.2.1.79
Succinate-semialdehyde dehydrogenase (NADP(+)).
based on mapping to UniProt P25526
Succinate semialdehyde + NADP(+) + H(2)O = succinate + NADPH.
-!- This enzyme participates in the degradation of glutamate and 4-aminobutyrate. -!- It is similar to EC 1.2.1.24 and EC 1.2.1.16 but is specific for NADP(+). -!- The enzyme from Escherichia coli is 20-fold more active with NADP(+) than NAD(+).

UniProtKB Entries (1)

P25526
GABD_ECOLI
Escherichia coli K-12
Succinate-semialdehyde dehydrogenase [NADP(+)] GabD

PDB Structure

PDB 3JZ4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions.
Langendorf, C.G., Key, T.L., Fenalti, G., Kan, W.T., Buckle, A.M., Caradoc-Davies, T., Tuck, K.L., Law, R.H., Whisstock, J.C.
Plos One