CATH Classification

Domain Context

CATH Clusters

Superfamily DUSP-like
Functional Family ubiquitin carboxyl-terminal hydrolase 15 isoform X1

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt P35123
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

P35123
UBP4_MOUSE
Mus musculus
Ubiquitin carboxyl-terminal hydrolase 4

PDB Structure

PDB 3JYU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the N-terminal domains of the ubiquitin specific peptidase 4 (USP4)
Bacik, J.P., Avvakumov, G., Walker, J.R., Xue, S., Dhe-Paganon, S.
To be Published