CATH Classification

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt O76074
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt P51160
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

P51160
PDE6C_HUMAN
Homo sapiens
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

PDB Structure

PDB 3JWQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit
Barren, B., Gakhar, L., Muradov, H., Boyd, K.K., Ramaswamy, S., Artemyev, N.O.
Embo J.