CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family Bifunctional dihydrofolate reductase-thymidylate synthase

Enzyme Information

UniProtKB Entries (1)

D9N170
D9N170_PLAFA
Plasmodium falciparum
Bifunctional dihydrofolate reductase-thymidylate synthase

PDB Structure

PDB 3JSU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate
Nzila, A., Rottmann, M., Chitnumsub, P., Kiara, S.M., Kamchonwongpaisan, S., Maneeruttanarungroj, C., Taweechai, S., Yeung, B.K., Goh, A., Lakshminarayana, S.B., Zou, B., Wong, J., Ma, N.L., Weaver, M., Keller, T.H., Dartois, V., Wittlin, S., Brun, R., Yuthavong, Y., Diagana, T.T.
Antimicrob.Agents Chemother.