CATH Classification

Domain Context

CATH Clusters

Superfamily Macrophage Migration Inhibitory Factor
Functional Family Macrophage migration inhibitory factor

Enzyme Information

5.3.3.12
L-dopachrome isomerase.
based on mapping to UniProt P14174
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
-!- Stereospecific for L-dopachrome (5,6-dioxo-2,3-5,6-tetrahydroindole- 2-carboxylate). -!- Dopachrome methyl ester is a substrate, but dopaminochrome (2,3- dihydroxyindolyl-5,6-quinone) is not (see also EC 4.1.1.84).
5.3.2.1
Phenylpyruvate tautomerase.
based on mapping to UniProt P14174
Keto-phenylpyruvate = enol-phenylpyruvate.
-!- Also acts on other arylpyruvates.

UniProtKB Entries (1)

P14174
MIF_HUMAN
Homo sapiens
Macrophage migration inhibitory factor

PDB Structure

PDB 3JSF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.
McLean, L.R., Zhang, Y., Li, H., Li, Z., Lukasczyk, U., Choi, Y.M., Han, Z., Prisco, J., Fordham, J., Tsay, J.T., Reiling, S., Vaz, R.J., Li, Y.
Bioorg.Med.Chem.Lett.