CATH Classification

Domain Context

CATH Clusters

Superfamily Actin; Chain A, domain 4
Functional Family Heat shock cognate 71 kDa protein

Enzyme Information

3.6.4.10
Non-chaperonin molecular chaperone ATPase.
based on mapping to UniProt P11021
ATP + H(2)O = ADP + phosphate.
-!- This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. -!- They comprise a number of heat-shock-cognate proteins. -!- They are also active in clathrin uncoating and in the oligomerization of actin.

UniProtKB Entries (1)

P11021
BIP_HUMAN
Homo sapiens
Endoplasmic reticulum chaperone BiP

PDB Structure

PDB 3IUC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78
Wisniewska, M., Karlberg, T., Lehtio, L., Johansson, I., Kotenyova, T., Moche, M., Schuler, H.
Plos One