CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.600 | Farnesyl Diphosphate Synthase |
|
1.10.600.10 | Farnesyl Diphosphate Synthase |
Domain Context
CATH Clusters
| Superfamily | Farnesyl Diphosphate Synthase |
| Functional Family |
Enzyme Information
| 2.5.1.81 |
Geranylfarnesyl diphosphate synthase.
based on mapping to UniProt Q8PYS1
Geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)- geranylfarnesyl diphosphate + diphosphate.
-!- The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis. -!- It prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate. -!- The enzyme from Aeropyrum pernix prefers farnesyl diphosphate as allylic substrate. -!- The enzyme is involved in the biosynthesis of C(25)-C(25) membrane lipids. -!- Formerly EC 2.5.1.n2.
|
UniProtKB Entries (1)
| Q8PYS1 |
GFPS_METMA
Methanosarcina mazei Go1
Geranylfarnesyl diphosphate synthase
|
PDB Structure
| PDB | 3IPI |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of a Geranyltranstransferase from the Methanosarcina mazei
To be Published
|