CATH Classification

Domain Context

CATH Clusters

Superfamily Bira Bifunctional Protein; Domain 2
Functional Family DNA polymerase subunit gamma-2, mitochondrial

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9UHN1
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P54098
DPOG1_HUMAN
Homo sapiens
DNA polymerase subunit gamma-1

PDB Structure

PDB 3IKM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations.
Lee, Y.S., Kennedy, W.D., Yin, Y.W.
Cell(Cambridge,Mass.)