CATH Classification

CATH Clusters

Superfamily 3.10.50.40
Functional Family PpiC-type peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q13526
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q13526
PIN1_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

PDB Structure

PDB 3IKD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based design of novel human Pin1 inhibitors (I).
Guo, C., Hou, X., Dong, L., Dagostino, E., Greasley, S., Ferre, R., Marakovits, J., Johnson, M.C., Matthews, D., Mroczkowski, B., Parge, H., Vanarsdale, T., Popoff, I., Piraino, J., Margosiak, S., Thomson, J., Los, G., Murray, B.W.
Bioorg.Med.Chem.Lett.