CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Ubiquitin carboxyl-terminal hydrolase

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt P45974
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

P45974
UBP5_HUMAN
Homo sapiens
Ubiquitin carboxyl-terminal hydrolase 5

PDB Structure

PDB 3IHP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Covalent Ubiquitin-Usp5 Complex
Walker, J.R., Avvakumov, G.V., Xue, S., Butler-Cole, C., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S.
To be Published