CATH Classification

Domain Context

CATH Clusters

Superfamily Topoisomerase I; Chain A, domain 3
Functional Family

Enzyme Information

5.6.2.2
DNA topoisomerase.
based on mapping to UniProt P32989
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.

UniProtKB Entries (1)

P32989
TOP1_VAR67
Variola virus human/India/Ind3/1967
DNA topoisomerase 1

PDB Structure

PDB 3IGC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Insights from the Structure of a Smallpox Virus Topoisomerase-DNA Transition State Mimic.
Perry, K., Hwang, Y., Bushman, F.D., Van Duyne, G.D.
Structure