CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.8.960
Functional Family Glutamate--cysteine ligase

Enzyme Information

6.3.2.2
Glutamate--cysteine ligase.
based on mapping to UniProt P32477
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L- cysteine.
-!- Can use L-aminohexanoate in place of glutamate.

UniProtKB Entries (1)

P32477
GSH1_YEAST
Saccharomyces cerevisiae S288C
Glutamate--cysteine ligase

PDB Structure

PDB 3IG8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanistic details of glutathione biosynthesis revealed by crystal structures of Saccharomyces cerevisiae glutamate cysteine ligase.
Biterova, E.I., Barycki, J.J.
J.Biol.Chem.