CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1280.10
Functional Family tRNA (guanine-N(1)-)-methyltransferase

Enzyme Information

2.1.1.228
tRNA (guanine(37)-N(1))-methyltransferase.
based on mapping to UniProt Q6G1R9
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

Q6G1R9
TRMD_BARHE
Bartonella henselae str. Houston-1
TRNA (guanine-N(1)-)-methyltransferase

PDB Structure

PDB 3IEF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of tRNA guanine-n1-methyltransferase from Bartonella henselae using MPCS.
Edwards, T.E., Stahl, G., Gerdts, C.J., Staker, B.L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), Seattle Structural Genomics Center for Infectious Disease (SSGCID)
To be Published