CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrodipicolinate Reductase; domain 2
Functional Family Glyceraldehyde-3-phosphate dehydrogenase

Enzyme Information

1.2.1.12
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
based on mapping to UniProt P22513
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
-!- Also acts very slowly on D-glyceraldehyde and some other aldehydes. -!- Thiols can replace phosphate.

UniProtKB Entries (1)

P22513
G3PG_TRYCR
Trypanosoma cruzi
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal

PDB Structure

PDB 3IDS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Glycosomal Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in complex with the irreversible iodoacetamide inhibitor
Balliano, T.L., Guido, R.V.C., Andricopulo, A.D., Oliva, G.
To be Published