CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family cAMP-dependent protein kinase catalytic subunit alpha

Enzyme Information

2.7.11.11
cAMP-dependent protein kinase.
based on mapping to UniProt P05132
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (2)

P05132
KAPCA_MOUSE
Mus musculus
CAMP-dependent protein kinase catalytic subunit alpha
P12369
KAP3_RAT
Rattus norvegicus
CAMP-dependent protein kinase type II-beta regulatory subunit

PDB Structure

PDB 3IDC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures.
Brown, S.H., Wu, J., Kim, C., Alberto, K., Taylor, S.S.
J.Mol.Biol.