CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P23284
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P23284
PPIB_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase B

PDB Structure

PDB 3ICH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis of Cyclophilin B Binding by the Calnexin/Calreticulin P-domain.
Kozlov, G., Bastos-Aristizabal, S., Maattanen, P., Rosenauer, A., Zheng, F., Killikelly, A., Trempe, J.F., Thomas, D.Y., Gehring, K.
J.Biol.Chem.