CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.210.20
Functional Family

Enzyme Information

1.13.11.47
3-hydroxy-4-oxoquinoline 2,4-dioxygenase.
based on mapping to UniProt O33472
3-hydroxy-1H-quinolin-4-one + O(2) = N-formylanthranilate + CO.
-!- Does not contain a metal center or organic cofactor. -!- Fission of two C-C bonds: 2,4-dioxygenolytic cleavage with concomitant release of carbon monoxide. -!- The enzyme from Pseudomonas putida is highly specific for this substrate. -!- Formerly EC 1.12.99.5 and EC 1.13.99.5.

UniProtKB Entries (1)

O33472
QDO_PSEPU
Pseudomonas putida
1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase

PDB Structure

PDB 3IBT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for cofactor-independent dioxygenation of N-heteroaromatic compounds at the alpha/beta-hydrolase fold.
Steiner, R.A., Janssen, H.J., Roversi, P., Oakley, A.J., Fetzner, S.
Proc.Natl.Acad.Sci.USA